Perryville had 16 shots with their first goal at the 13 minute mark scored by Kasey Riney with the assist by Jen Koeing.
The Lady Bulldogs had 11 shots and keeper Audra Wooley had 10 saves.
"I was very happy with the way we played. This was our first game of the season and Perryville's sixth game," said Sikeston coach Derrick Long.
Amber Hacker and Kris Shremp showed to be strong for Perryville. Hacker scored off a Shremp assist to make it 2-0. And 17 minutes later Shremp scored a goal with the assist from Hacker to make it 3-0 a the half.
"This game gave us some good experience and we were a little off, we just couldn't get up to game speed," Long said.
Ashley Hadler scored the last point of the game for Perryville with an assist from Hacker at the 79 minute mark to give them the 4-0 victory.
But Sikeston showed good defense on their back side.
"Defensively Amber Coffee and Molly Brinkmeyer played really well in the back, but Perryville just packed it in and got a few good shots off," Long said.
With the next game at 4 p.m. on Tuesday, at Fredricktown the Lady Bulldogs are preparing to get their first win of the season over the Blackcats.