The Dons, who trailed by 20 points for much of the contest, had only one productive quarter when they garnered 18 points in the fourth.
In the opening minutes of the first period, it appeared that the two teams would play a close contest as the Dons scored the first points.
The Eagles were a little slow to get into the flow and trailed for most of the period until Malcom Long, Laterrance Newsom and Jordan Kimball each buried a 3-pointer to give Central the confidence and momentum to take control of the contest.
Doniphan managed to knot the score at eight in the waning minutes of the quarter, but a 5-0 run put the Eagles ahead to stay. They led by a 13-8 count at the end of the quarter.
Nine Eagles got into the scoring column with Brandon Waters' 13 leading the way. Edgar Givens chipped in a dozen.
Doniphan was led by Matt Rogers who took game scoring honors with 16. Devin Simms added 13 and Brett Reed 12.
"We've been off for two weeks, but they've been working in practice, and giving me what I want to see. I wanted them to be rewarded and they came out and played with a lot of energy," said Central coach Scott Kruse. "In the third quarter we came out and played and rebounded well and I'm proud for them. We've played a great schedule up to now, and it's good to see them come out and expect to win every time they play."
New Madrid's balanced attack really began to put the game on ice in the second quarter as six players scored. Newsom's two 3-pointers led the way and the Eagles led by a 30-19 score at the half.
The game really got lop-sided in the third stanza when the Eagles' effort on both ends of the floor became too much for the visitors. Doniphan was held to a mere seven points in the quarter, three of them on free throws. Meanwhile, Central scored 18 to lead 47-26 after three.
Despite the strong 18-point effort by the Dons in the final period, New Madrid was able to coast to the 14-point win.
The junior Eagles ran away from the Doniphan jayvee 59-27.
New Madrid played in the Massac Shootout Saturday night. Results will be in Monday's paper.