It's Sikeston's first championship in the tournament in the 11 years they've been in the event.
Bulldog head coach Lee Brooks was thrilled about the victory.
"It took us 11 years to win it, but it's great to pull it off this year," said Brooks. "The girls just went out and worked hard. They knew and we felt like we could do it. I'm not surprised that they did what they did."
Sikeston (4-1) led 17-11 after one quarter and 24-19 at the half.
They extended the lead to 39-25 heading into the fourth quarter.
Brooks is hoping that the victory is the beginning of a strong program for Sikeston.
"It's gigantic," said Brooks. "When the girls see that, they can see that we're building a quality program. I've tried to impress upon these kids about the importance of building a quality program for the future. At this point, they're leaving a legacy. They made history with this. This will make kids in the younger programs say, 'I want to do that, too.'"
But the younger programs will have to wait their turn, as the future for Lady Bulldogs basketball is now.
Sophomore Paige Silverthorn had the top day for Sikeston as she scored 15 points.
"Paige is our only returning starter," said Brooks. "She started as a freshman. She's going threw some changes. We've fought back and forth and we've exchanged ideas. She's still learning, but she shows me some things sometimes that amazes me. She just took over (Saturday) and she's shown me that she deserves that point guard position."
Sikeston also got 10 points out of sophomore Allison Blurton, eight out of Whitney McCray and seven out of Mia Welch.
Delta, which was the state runnerup in Class 1 last year, was led by Shea Smith's 16 points. Sarah Cook added 13 points.
The seedings for the Twin Rivers Christmas Tournament were also released. Of the 16-team event, Sikeston garnered the fourth seed. Dexter, which gave Sikeston its only loss, was seeded No. 1.