The Bulldogs controlled the boards against the Hawks and clamped down defensively during the middle quarters to put the game away.
The score was tied 13-13 after one quarter and the Hawks led briefly in the second quarter 15-13.
But the Bulldogs woke up, going on a 17-0 run to lead 30-15 on a Lavar Morgan 3-pointer with 3:13 left in the half.
Morgan hit a season-high four 3-pointers en route to scoring 18 points with nine rebounds, six assists, two blocks and two steals.
"We knew he could shoot and I told them that they needed to cover him, but evidently they didn't believe me because they wouldn't get out on him," said Kelly head coach Nick Lanpher. "They didn't recognize him when he had the ball and he had wide open looks. I mean you should hit those shots."
The Bulldogs also got a solid outing out of Lontas McClinton, who scored a game-high 20 points with 10 rebounds, two steals and two blocks.
"They got away from us," said Lanpher. "McClinton got loose down underneath there two or three times. We didn't defend him like we were supposed to. They beat us on the boards real bad."
The Bulldogs eventually led 35-21 at the half. Kelly (7-10) would not get any closer than 14 the rest of the way.
Morgan, who has switched back and forth between forward and guard, had 14 of his points in the first half. All of it came from the perimeter.
"He gets a look at both positions," said Sikeston head coach Gregg Holifield. "He didn't play in the post very much tonight. But he's a good perimeter and he's a good post player. He's a good inside-outside guy and he's going to play both spots. He just has to continue to work like he has been."
The Bulldogs quickly turned the game into a rout in the third quarter as they led 50-30 entering the fourth quarter.
Sikeston led by as much as 54-30 with 6:40 left in the game when the benches were cleared.
"I knew they would come out and play very well early and they did," said Holifield. "They're well-coached, they're under control. They battled us hard, but I think our defense picked up in the second quarter.
"We had a little burst there where we shot the basketball well. We got some looks and we were fortunate enough to hit the shots and that was the difference in the game."
Junior forward Freddie Wiggins posted a season-best eight points with six rebounds.
"He played with much more confidence, he kind of got rolling a little bit," said Holifield. "Freddie's a good player, he just needs some confidence and that's going to come with time."
Ben Anderson (seven rebounds, five blocked shots) and Lawrence Davis (six assists) also had good numbers.
The Bulldogs grabbed 44 rebounds as a team in the game.
Kelly was led in scoring by Mike Scherer's 14 points. No other Hawk reached double figures.
"We came out early real good," said Lanpher. "We were ready and we were confident. But we just lost track of them. I can't figure it out. But playing teams like this won't hurt us. We play a real tough schedule with Charleston, Sikeston and Jackson and some others."
The Bulldogs played Portageville on Saturday for their homecoming. Results from that game will be in Monday's edition.
Sikeston will be on the road on Friday when they play state-ranked Poplar Bluff at 6 p.m.
Kelly will host Puxico next Friday at 6:30 p.m.
The Sikeston jayvee team improved to 10-4 on the season with a 46-39 win against Kelly.
The Bulldogs led for most of the game, taking a 10-8 lead after one quarter and a 19-17 edge at the half.
They extended the lead to 30-27 entering the fourth quarter.
Sikeston led by as much as nine late in the fourth quarter on a Johnny Bland slam dunk, but the Hawks rallied to cut the lead to three.
Sikeston's Apollo Patterson sealed the game with six consecutive free throws in the final minute.
Patterson led all scorers with 11 points while grabbing six rebounds. Brandon Williams and Trey Spence followed up with six points each.
Kelly, which won the Scott-Mississippi Conference JV Tournament last week, has now lost two in a row to fall to 13-4 on the season.
Kendall Deason led the Hawks with 10 points. Mike Glastetter and Kent Deason each had eight points.