Sikeston falls to 14-12 on the season and 2-4 in district play.
Unit 114 lost the first game 9-8 and dropped the second game 14-13.
In the first game, Sikeston's pitching got battered.
Caleb Davidson got the start before being pulled. Logan Kirkpatrick ended up as the losing pitcher. Timmy Hart threw the final three innings in relief.
Darrin Dicus, Stephen Beydler and Tyler Selvig each had two hits for Sikeston.
Hart and Jason Issacs both collected one hit apiece. Charlie Bohannon had three walks.
"It seems to me like we've had a lot of one-run games this year," said Sikeston coach Steve Beydler. "When we win, we seem to win big, when we lose we barely fall short. We've played a lot of games in one week and we're getting to that point where we're trying to make something happen at the right time, but we fell a little short.
"We're still hitting the ball, but we left a lot of guys stranded tonight. We left the bases loaded once and if we can get just one of those guys across we've got a tie game."
In the second game, Sikeston fell behind 11-0 and was on the verge of being run-ruled by Cape.
But Unit 114 put together a big rally, scoring seven runs in the fourth inning to get back in the game.
Sikeston eventually cut the lead to 14-10 and pulled to within one run in the bottom of the seventh, but came up short.
"We were trying to get some guys some time on the mound to see what we had," said Beydler. "You never know what you're going to need. For the most part I'm pretty pleased with what I saw. We had just one big inning where they scored a lot.
"We basically pitched guys that normally don't pitch in the second game. We could've rolled over and died, but we came all the way back and barely fell short."
Josh Carlyle was the losing pitcher for Sikeston. Gabe McClung, Beydler and Jordan Williams also saw time on the hill.
Beydler, Carlyle and Bohannon led the way for Sikeston with two hits apiece. Selvig, Michael Brown, McClung and Kirkpatrick each had one hit. Williams drew three walks.
Sikeston Unit 114 will host Scott County tonight at 6 p.m. in another doubleheader.