Sikeston (9-12) outscored Scott City 20-11 in the fourth quarter and sank 10-of-13 free throws in the final frame to seal the victory.
Sikeston was 13-of-17 from the line on the night.
"We've been stressing the issue of free throws," said Sikeston coach Tiffany King. "It's getting close to district time and free throws will win close games. When they put us on the line we made them."
Junior guard Allison Blurton led the Lady Bulldogs with 18 points. Robyn Morris added 14 points followed up by freshman Martika Davis' 10 points.
Valerie Gibbons led Scott City with 14 points.
"Last night after the game we told the girls to shake this game off," said King. "The girls came out and did everything we asked them to. Stepped up their defense and our press really bothered Scott City at times. We just played hard tonight. It was a group effort."
Sikeston will play at Jackson on Monday night at 6 p.m.
NEW MADRID - Delta led 38-34 after three quarters, but the Bobcats were outscored by New Madrid County Central 20-5 in the fourth and lost on the road.
Delta came into the game ranked No. 9 in the state in Class 1.
NMCC was led by Betsy White's 14 points.
Tsia Matthews and Lameka Newsom followed up with 12 and 11 points respectively. Micah Nesselrodt added 10 points.
Ashley Deprow led Delta (13-4) with 12 points, and Kaci Menz added 10.
Oran jumped over the .500 mark with its second road victory in two nights.
The Eagles (7-6) outscored Charleston 20-7 in the third quarter for the difference.
Amanda Eftink scored 10 points to lead Oran, which had won in overtime Wednesday at Sikeston.
Chaffee survived a second-half comeback and won at home. Kegan Orr led the Devils (6-12) with 15 points, and Mindy Hendrix added 10.