The Lady Bulldogs were caught off guard in the first set, losing 6-15.
Sikeston was able to bounce back though, winning the final two sets by a score of 15-3.
"We were slow out of the blocks, then slowly but surly, we gained momentum," said Sikeston coach Steve Beydler. "By the end of the third game, we had our engines running pretty smoothly."
Emily Slayten had 13 service points with four aces and one kill. Joy Daniel served up eight points and four aces with nine kills and two blocks.
Paige Kaiser also had a big night with four points, one ace and seven kills. Rachael Vining contributed six points and four kills.
"Between the first and second game, I reminded the girls this was a conference match that we could ill-afford to lose," said Beydler. "Things kind of changed from that point on. Once we started playing our own game, things flowed."
Berneatress Hunt had five blocks and three kills. Lindsey Davis had three points, Tara Shoemaker had two points, Maggie Pfefferkorn added two points, and Erin Box had two points and one ace.
"I'll hand it to Chaffee," said Beydler. "They're much improved from any team they've had the last few years. In the first game, they really caused us problems."
Chaffee falls to 5-10 with the loss. The Lady Red Devils will face Marquand in the first round of the Scott City Tournament on Saturday at 10 a.m.
"Sikeston came out a little sluggish tonight, and we were able to take advantage of some of their mistakes," said Chaffee coach David Mirly. "They stepped up their level of play, and we couldn't keep up with them. Until we start playing with some consistency, we're never going to reach our potential."
Sikeston improves to 9-7-2 with the win. They will travel to Dexter on Monday.
In Thursday's junior varsity match, Sikeston defeated Chaffee 12-15, 15-13, 15-6.
Audra Wooley had 12 points, five aces, eight kills and one block. Amber Anthony had 12 points, two aces and two kills. Erin Dement added six points and one ace. Robyne Morris finished with six points, three aces, five kills and four blocks.
Latisia Peet scored two points, two aces and three kills. Cassie Patterson contributed six points with one ace.
MALDEN -- Charleston's volleyball team was defeated by Malden in straight sets on Thursday. The Lady Bluejays lost the first set 10-15, then the second 12-15.
Charleston (1-13) will travel to Oak Ridge on Tuesday for a 6 p.m. match.