The 135-pounder pinned Cape Central's Don Coonce in 1:20, helping the Bulldogs beat the Tigers 54-27.
It was Weeks' 101st career win. The record stands at 105, set by Jerry Winberry from 1990 to 1994.
"Kyle has been wrestling varsity for us since he was a freshman," said Sikeston coach Chris Hodgkiss. "Getting 100 wins in a career is pretty impressive. The reason he's been able to do it is because he has been steady all those years. He competed well, even as a freshman. We look for him to break it here in the next week or two."
Weeks' win was one of several Sikeston highlights in Tuesday's match. The Bulldogs won eight matches by pin, improving their dual record to 4-2 this season.
"I was very pleased with our effort tonight," said Hodgkiss. "This was one of the best dual meets we've wrestled in the last couple of years. The guys wanted this dual meet, and you could tell by how aggressive they were."
Sikeston struggled in the light weights.
Cape Central's Chris Griffith won by forfeit in the 103 class. At 112, Cape's Aja Reutzel pinned Ben Powers in 3:05. At 119, Cape's Matt Lathum beat Cody Ryan by a score of 7-3. At 125, Cape's Jonathan Poston won by forfeit.
The Bulldogs made up for lost time in the heavier divisions. In the 130 class, Shawn Cooper pinned Cape's Tyler Yeargain in 1:06.
"That was a big win," said Hodgkiss. "(Yeargain) beat him earlier in the year. When Shawn came out and pinned him, it was a big momentum swing. You could feel a difference in our team from that point on."
At 140, Cody Weeks pinned Cape's Garrett New in 1:32. In the 145 division, Tony Reynolds pinned Cape's Josh Smoot in 3:23. At 152, Cullen Looney was pinned by Cape's Cory Hukey in 1:28. In the 160 class, Lance Berry pinned Cape's Russell Smith in 1:29. With the victory, Looney improves his personal record to 20-2 on the season. He is currently ranked No. 5 in the state.
"Lance has been steady throughout the entire year," said Hodgkiss. "We've been able to depend on him in every tournament and every dual meet."
In the 171 class, Scotty Keenan pinned Cape's John Moseby in 1:44. Keenan is ranked No. 7 in the state with a season record of 17-3.
In the 189 class, Malcolm Williams won by forfeit. At 215, Andy Croxford pinned Cape's Jason Poole in 44 seconds. Croxford is No. 8 in the state with a record of 16-6. In the heavyweight class, Joe Johnson pinned Cape's Chase Yager in 13 seconds. Johnson is No. 4 in the state with a record of 17-5.
Sikeston's wrestling team will be back in action this Friday, competing in the St. Charles Tournament.
"It's a 12-team tournament up in the St. Louis area," explained Hodgkiss. "It's going to be good for us to get out of Southeast Missouri and wrestle some tough competition. This will be a good test for us."
Sikeston won Tuesday's junior varsity match, 30-10. Sikeston winners were Logan White, Justin Morton, Matt Knickman, Ryan Dicus and Brandon Hale. The junior varsity team improves to 4-2 with the win.