Sikeston scored 214.5 points to beat four other teams. Poplar Bluff finished with 176 points followed by Charleston with 171 points.
Ste. Genevieve (88 points) and Farmington (59 points) rounded out the field.
There were 383 swimmers competing in the meet with 22 records falling.
Sikeston's Morgan Fraser set one new conference record in the 11-12-year-old girls division in the 50-yard breaststroke with a time of 34.78.
Natalie Stevens set three new team records in the girls 8-year-old and under 25-yard freestyle (17.07), 25-yard backstroke (19.91) and 25-yard butterfly (18.80), in which she placed first.
Sikeston had two other swimmers that placed first in a heat. Gratten Allen finished first in the boys 11-12 50 yard breaststroke.
Also, Mary Anne Kendig placed first in the girls 9-10 50 yard breaststroke.