The Lady Bulldogs trailed just 2-1 at the 70 minute mark, before Poplar Bluff scored two late goals to pull away for the win.
"I think it was the best game we played all year," said Sikeston coach Derrick Long. "We seemed to come together as a team. We were a cohesive group tonight instead of playing sporadic like we did against St. Vincent."
Last year Poplar Bluff beat Sikeston twice, 7-0 and 8-0.
In Thursday's match, things looked bleak for Sikeston in the early stages when leading scorer Allison Blurton went down with the stomach flu.
Poplar Bluff jumped on top at the 24 minute mark off an unassisted goal by Lauren Ploetz. Sikeston fired right back at 32 minutes as Paige Silverthorn scored on an assist from Caroline McClung.
Bluff's Kristin Ploetz then scored at 39 minutes to give the Lady Mules a 2-1 advantage at the break. In the second half, Andrea Campbell scored at 70 minutes and then Sikeston scored an own-goal at 74 minutes to make the final 4-1.
"We were in the game the whole time," said Long. "They scored a couple of goals late to pull away. It was a lot closer game than that. I was really proud of our girls. They played Poplar Bluff really tough."
Sikeston keeper Whitney Wallace finished with eight saves. Poplar Bluff's keeper ended with five.
Sikeston (1-2) will face Carbondale tonight in the Carbondale Tournament at 7 p.m.
In Thursday's junior varsity match, Poplar Bluff defeated Sikeston 1-0. Catherine Bradey scored the only goal of the game.
Sikeston keeper Audra Wooley finished with 12 saves. Sikeston's junior varsity falls to 0-2 with the loss and will travel to Jackson on Monday.