Sikeston raced out to an 18-2 lead to start the game and was never threatened.
"We came out and got a good lead and held on to it," said Sikeston coach Gregg Holifield. "We hit some shots, played better defense and did some good things."
The win helped ease some of the pain from their four previous losses, three of which were close games in the end. "That aspect is important because we've lost some heartbreaking games in three of our last four," said Holifield. "We were right there in the end and couldn't pull them out. So to snap the streak is always a good thing. We were really needing to get a win."
Sikeston led 20-8 after one quarter and 39-13 at the half.
Sikeston was led by Kash Bratcher's 12 points and four assists and three steals. Joel Nabors added 10 points and nine rebounds.
Josh Alvarado had five rebounds and five steals.
Travis Randolph led Oran (1-16) with seven points.
The Eagles have now lost eight in a row.
"Oran's doing a good job -- they're going to have a fine team in another year or two," said Holifield. "They're rebuilding and going through some growing pains right now but things will get better for them down the road."
Sikeston will host Cape Central on Friday night for homecoming. Oran will host Advance next Tuesday night.
The Sikeston JV team improved to 6-10 on the season with a 54-47 overtime victory against Oran.
Sikeston trailed 24-19 at the half but took a 34-31 lead heading into the fourth quarter.
Oran's Chase Seyer tied the game on a free throw with seven seconds left to send the game into overtime.
Sikeston went 7-of-8 from the free throw line in overtime to seal the victory.
The JV Bulldogs were led by Andrew Sales' 13 points and six rebounds. Blake Taylor added 12 points.
Tarryl Booker had five points, nine rebounds, four steals and three blocked shots. Freshman Tommie Strong had seven rebounds off the bench.
Steven Mock led Oran with 13 points.