Sikeston trailed 15-0 in the third quarter but rattled off 28 unanswered points to pull out the dramatic victory.
"It's a nice win for our kids, especially to come from behind like we did," said Sikeston coach Alan Scheeter. "Hopefully this will get our varsity jump-started and we can get two wins this week. The kids were emotional after the game and they were pumped."
The Bulldogs scored their first touchdown on an Adrian Douglas 3-yard run with three minutes left in the third quarter. Michael Geralds tacked on the two-point conversion run.
Still trailing through most of the fourth quarter, Sikeston scored 20 points with less than two minutes remaining in the game.
Geralds scored on a 3-yard run with 1:50 left in the game and then added the go-ahead two-point conversion run to take a 16-15 lead.
Following a Julian Beard interception, Geralds then broke loose on the very next play from 40 yards out to extend the Bulldogs' lead to 22-15 with 1:07 left.
Sikeston sealed the game for good when Robbie Howard returned an interception 45 yards for a touchdown with 20 seconds left.
"We waited a little while to get started, but once we did we blocked well and our backs ran hard," said Scheeter. "We never gave up. You could just tell that they knew they would come back and win that game. They just knew it. Our offensive line took control in the second half. Mike Geralds ran hard and so did Adrian Douglas."
Sikeston's junior varsity will play at Caruthersville next Monday at 6 p.m.