The Lady Bulldogs, seeded fifth, stayed close to fourth-seeded Notre Dame early, trailing just 15-11 in the second quarter.
But things quickly unraveled after freshman guard Jordi Ferrell went down with a knee injury, dealing a severe hit to the Lady Bulldogs' already thing bench.
"When you play five girls after Jordi got hurt, they're going to get tired," said Sikeston coach Tiffany King. "They were running eight, nine, 10 girls in and out. We just got tired and the girls got down on themselves."
Notre Dame was able to build a 23-14 halftime lead and they put the game away with a 17-3 run in the third quarter.
They led 40-17 heading into the final frame.
"Notre Dame kind of took us out of our normal routine of pressing," said King. "We got some girls in foul trouble too so we couldn't do some of our normal things with our lack of depth."
Sikeston also had trouble connecting on anything from the field as they had several point blank looks simply rim off. They were also just 4-of-14 from the free throw line.
"We couldn't hit anythig in the first half or the second half," said King. "We got plenty of looks at the basket, some were close, but we just couldn't hit. That's something that comes down to being tired and lack of concentration."
Notre Dame got a game-high 22 points from sophomore Meridith Medlin, including four 3-pointers. Sophomore Kristain Burger added 12 points.
Freshman Amber Minner led the Lady Bulldogs with 12 points. Junior Allison Blurton followed up with 11 points.
Sikeston will return every single member of the team for next season. Six freshmen, two sophomores and three juniors comprised the team this year.
The team's roller coaster ride began when longtime head coach Lee Brooks unexpectedly resigned after one game.
As the year progressed, the team's numbers dwindled as several girls quit and some were injured for the balance of the season.
Considering the circumstances, King, who was thrust into the head coaching role, was pleased with her girls.
"I told the girls that they're winners no matter what," said King. "They stuck with us from the beginning to the end with all the controversy and all the changes. They're just winners for fighting through it."
Notre Dame will play top-seeded Dexter tomorrow in the semifinals at 6 p.m.