Jackson (7-1, 4-0 SEMO Conference) never trailed as they led 3-0 and withstood a seventh inning rally by the Bulldogs.
Sikeston (7-3, 3-1) placed runners on first and second with two outs in the bottom of the seventh, but Jackson pitcher Tyler Beussink was able to get out of the jam with a strikeout.
This coming after a scare by Sikeston's Cullen DeHart, who sent a foul ball over the right field fence that would have won the game if not for a matter of feet.
It was the second ball DeHart had hit over the fence that just barely hooked foul. He had one earlier in the game in the fifth inning on one that would've tied the game.
"He hit them hard and hit them good and they were out of here, but he just couldn't keep them fair," said Sikeston coach Kevin Self. "The little kid did a good job of setting him up with a fastball and then going away from him."
Jackson got on the board in the top of the second with four hits. Joel Penrod's double to left field started the scoring for the Indians. Beussink also had a run-scoring single.
Jackson pushed the lead 5-0 after Rex Meyr drew a two-out walk.
Derrick Biri singled him home and advanced to third on a two-base error. Biri then scored on a passed ball for the Indians' other run.
Sikeston cut the lead to 5-1 in the bottom of the fourth on Tyler Baker's RBI-
single to left field to bring home Josh Jackson.
"We knew even when we got the lead early that Sikeston was going to come back," said Jackson coach Rex Crosnoe. "They're too good of a team. We had a few miscues and we were lucky to pull it out at the end."
Sikeston cut the lead to 5-3 in the bottom of the fifth on Jackson's two-run double that just missed clearing the fence in left field.
But Beussink was able to get the next two Bulldogs hitters out to thwart the rally. Sikeston couldn't score again.
"We knew they were a solid club coming in and I kept telling them that three runs and five runs was not enough," said Crosnoe.
"They're a quality team. I know everybody thinks they lost so much from last year, but we knew they were going to be good and a lot of teams are finding that out."
Beussink threw all seven innings, allowing just five hits and three runs (two earned). He struck out three and walked none.
Biri and Beussink each had two hits for the Indians.
Sikeston's Bryce Wibbenmeyer took the loss in 3 1/3 innings pitched. He allowed eight hits and five runs with one strikeout and two walks.
"He threw all right -- they hit some ground balls that found some holes," said Self.
"Really the only ball they hit hard was the double. It was just not our day today. Every little break seemed to fall their way."
DeHart threw 3 2/3 innings of scoreless relief. He allowed two hits and two walks with one strikeout.
J.R. Bizzell, Jackson, Baker, Matt Limbaugh and Eric Chappell had Sikeston's only hits.
Sikeston will travel to Charleston on Tuesday at 4 p.m. The Bulldogs will have makeup games with Kennett and Dexter on Wednesday and Thursday respectively.