Jackson (20-3) jumped out to a 20-4 lead after one quarter and never looked back.
"They're a superior team," said Sikeston head coach Lee Brooks. "Any time you've got a state-ranked team and a quality program like that, you just come out and try to hang on."
Jackson extended the lead to 39-10 at the half. The Lady Indians led 53-18 heading into the fourth where the mercy rule was in effect.
"Our intensity was pretty good, even when we got the lead I thought we kept playing," said first year Jackson head coach Sam Sides. "You don't want to get sloppy just because you got a lead. We gave up some easy shots. Their post player, No. 50 (Whitney McCray), we let her take the ball to the basket too many times. We didn't defend her as well as we should have."
McCray led the Lady Bulldogs with 10 points. Mia Welch followed up with six points.
Sikeston only had five players score.
"Jackson turns it up on defense as well as anybody," said Brooks. "I like that. I want our kids to play against that kind of defense. But we didn't execute and we came out and stood around."
Jackson had nine different players score. Kelly Loos led the way with 11 points. Ashley Bartels followed up with 10 points.
"All I can tell (Sikeston) is keep working," said Sides. "I think you've got to have a passion for it. A big advantage I think we have over Sikeston and other schools, is that our girls are into it. They have a passion for it and you've got to put a lot of time into it. If they keep working hard good things will happen."
Sikeston will play at Charleston on Thursday at 6 p.m.
Sikeston lost Monday's JV game with Jackson 57-18. Amanda Peiffer led Jackson with 12 points.
Sikeston got six points out of Tiarra Blackmon. Alyson Friend and Shaketa Ransom each had four points. Amber Anthony had three points and Lotoya Gipson added one point.