Sikeston led 35-14 at half and outscored Charleston 27-5 in the third quarter, to put the game away.
Whitney McCray led Sikeston with 18 points. Allison Blurton had 16 points and Amber Minner chipped in with nine points.
Phillicia Turner led Charleston with 11 points.
Sikeston (17-6) hosts Cape Central on Monday night.
The Oran Lady Eagles won on the road at East Prairie on Thursday night, with a 68-32 win over the Lady Eagles.
Oran led 41-17 at the half and cruised the rest of the way. Tiffany Glastetter led Oran with 21 points.
Erica Michelsen had 14 points and Wendy Eftink chipped in with 11 points for the Lady Eagles.
Madelyn Brannam had nine points for East Prairie to lead the Lady Eagles. Brittany Woodard scored seven points for East Prairie.
Oran (13-8) hosts St. Vincent on Monday.
The Delta girls basketball team hammered visiting Woodland 70-37 en route to its 20th victory on Thursday night.
The Bobcats (20-1) put Woodland away early with a 26-8 first-quarter edge. Shea Smith scored a game-high 22 points for Delta. Kaci Menz added 15 points, Ashley Deprow had 13 and Kayla Seabaugh added 12. Sasha Hutson and Courtney Glastetter paced the Cardinals with 10 points each.
After opening the season with 16 straight losses, Scott City finally broke through with a road victory over Meadow Heights.
"You would've thought we won the state championship," Scott City coach John Nanney said of his team.
Nora Glastetter paced the Rams with 16 points, while Kelley Hicks and Whitney Tapley finished with 11 points apiece. Amanda Hendrickson led Meadow Heights (1-15) with eight points.
Perryville wrapped up the Jefferson County Conference regular season title with a pounding of visiting Grandview. The Pirates (15-6, 8-1 JCC) exploded in the third quarter, outscoring Grandview 31-2. Annette Weibrecht led Perryville with 16 points. Amber Hacker had 12, Jessica Abernathy had 11 and Bethany Steffens and Chastity Marr chipped in 10 apiece.
PORTAGEVILLE -- The Portageville Bulldogs improved to 14-6 on the season with a 62-31 home victory against Gideon on Thursday.
The Bulldogs had no trouble with the visiting team as they built a 42-21 halftime lead.
Cory Chamberlain led Portageville with 17 points. Trey Mosby added 14 points and Patrick Morton had 11 points.