The third-seeded Lady Bulldogs jumped out to an early lead and cruised the rest of the way to a 68-36 victory against sixth-seeded Chaffee.
Sikeston (1-2) jumped out to an 18-12 first quarter lead and blew the game open in the second and third quarters.
Sikeston led 35-20 at halftime and extended the lead to 57-30 heading into the fourth quarter.
"They moved pretty good -- they were running the ball pretty well at times," said Sikeston coach Fred Johnson. "We had too many turnovers, but overall it was a pretty good game. Our defense was sporadic, but I guess you expect that when you're trying to do the things we're doing. I just gotta take what we get. Simple as that. I saw some positive things. We've just got to get a little better. It's going to take time. It's still early. All these games don't matter right now. The district's what I want."
Sikeston saw some balance in the scoring column with Latoya Gipson leading the way with 20 points. Allison Blurton pumped in 15 points while Martika Davis added 14 points.
"That's good when you get balanced scoring like that," said Johnson. "That means people are working and putting the ball in the hole. We've just got to keep plugging away and keep doing the things it takes to win."
Chaffee was led by Mindy Hendrix with 11 points and Kegan Orr with 10 points.
Sikeston plays Kelly tonight at 7:30 in a semifinal game. Chaffee will play tonight against Scott City in a consolation semifinal.
In a second round game, Delta pounded Oran 65-22 to advance to the final game in the tournament.
Delta led 19-2 after one quarter and 33-8 heading into halftime.
Delta (4-0) was led by Shea Smith's 15 points. Kaci Menz and Kayla Seabaugh each had 14 points.
Oran was led by Tiffany Glastetter's nine points.
Oran plays Saturday at 3 p.m. in the third place game. while Delta awaits the winner of the Kelly-Sikeston game for the championship on Saturday at 4:30.