Notre Dame, ranked third in state in Class 2A, was led by 6-7 Ryan Willen, who played a big role in the win for the visiting Bulldogs.
Willen headed in the first goal at the 11 minute mark in the first half to put Notre Dame on top. The score remained 1-0 until half time.
"Willen headed one in, and we were trying to mark him off on another one," Sikeston head coach Derrick Long said. "It just went right across to another guy for a score. He was the X-factor tonight."
In the second half, Notre Dame received two more goals. The first came at the 44 minute mark when a pass from Ty Williams was received from Brock Dirnberger, who put it in for the goal.
"There's a reason they're ranked third in the state," Long said. "They're a good team."
"They had a lot of shots on goal," he added. "They had 16 shots on goal, and had 15 more that were either over the goal or off to the side of the goal."
Despite the loss, Long said that he and his squad took a lot from the game.
"We chipped off one goal from the last time we played them," he said. "We're going to keep fighting when we play these teams. We don't have a lot of quit in this team. That's why I look forward to coming out here every night."
Sikeston recorded three shots on goal, and keeper Scott Droddy saved 13 of the 16 shots on goal from visiting Notre Dame.
Sikeston will head to Cape Central tonight to play the Tigers.