Dexter (5-2) led from the opening tip in a 71-21 win over struggling Sikeston (1-5).
"We've got to find some confidence and learn to trust our teammates," said Sikeston coach Homer Jackson. "Right now, we need a win to build that confidence."
The Bearcats ran out to an 18-0 lead before the Bulldogs finally sank a field goal with a minute left in the first quarter. Dexter led 24-2 going into the second quarter.
Another extended offensive drought by Sikeston saw the Dexter lead increase to 33-2 before Latoya Gipson, the Bulldogs lone senior, hit a two-pointer with 3 minutes left in the half. Gipson, who led the Bulldogs with 10 points, scored another basket late and Brittany Jones' buzzer-beating trey set the halftime score at 42-9.
Sikeston, already lacking quality depth, was further hampered by the loss of 6-foot-1 freshman post Monika Gray-el, who was forced to the bench with three fouls at the 3-minute mark of the first quarter.
In stark contrast to the Bulldogs' offensive ineffectiveness, the Bearcats got scoring contributions from 10 different players against a rather passive Bulldog defense.
Sikeston's shaky ballhandling and passing aided an opportunistic Dexter defense which created 32 turnovers, 21 in the first half.
Dexter, coming off a tough seven-point loss to Notre Dame the previous night, kept it rolling after the break to take a 59-14 lead into the final quarter with the mercy clock ticking.
Topping Dexter's scoring parade was Amanda Dooley, Jill Temples and Haylee Finch with 12, 11 and 10 points, respectively. Ashlee Taylor added nine and Molly Burleson eight.
Amber Minner was the scoring runner-up for Sikeston with five points.
Dexter also won the junior varsity game, 48-14.
Tasneem Ware paced the Bulldogs with eight points and Mary Deason added five.
Both Sikeston and Dexter return to action on Saturday in the Lady Royals Christmas Classic at Twin Rivers.
Dexter, the No. 2 seed, meets No. 15 Charleston at 2 p.m. while Sikeston, the No. 7 seed, takes on No. 10 Neelyville at 6:30 p.m.