Scheduled for 6 p.m. until midnight, the ball is an opportunity to dress up in formal wear and support the community's hospital.
"This year's theme is 'An Evening Aboard the Queen Elizabeth,'" said Rhonda Menz, general co-chairperson for the event.
"It's a great way to decorate," said Sharon Urhahn, MDMC's director of marketing. "Everything will be like you are walking onto a cruise ship."
Musical entertainment by "The Chessmen," a band from Nashville, Tenn., will begin at 8 p.m. "They're going to be singing a variety of hits from the '50s through today," Menz said.
In what has become a favorite feature of these parties over the last few years, casino table games will also be part of the event.
Chips to bet on the games are included with each admission ticket with additional chips available in exchange for donations.
At the end of the night, chips are converted into chances for door prizes.
Dinner will not be served but there will be "heavy hor d'oeuvres" provided for guests.
The Hospital Ball is more than just a fun-filled night out on the town, however. "The Ball is one of the biggest fundraisers in the Sikeston community," said Michelle Worth, co-chair for the event.
"Proceeds raised this year will go directly toward the purchase of 11 new bedside monitors for the Intensive Care Unit," Menz said. "The monitors are over 10 years old; repairs can get expensive." She added that with the technological advances made over the last decade, "it is time to replace them."
"These monitors are used 24 hours per day, seven days per week," Urhahn noted.
With over 800 employees and an annual payroll of over $34 million, Missouri Delta Medical Center is an important part of the community. "We are so fortunate to have Missouri Delta serving our community," Worth said. "We have excellent qualified physicians, nurses and staff."
"The Sikeston community has continued to support Missouri Delta Medical Center and the employees continue to give back to the community," Menz said.
"When you give to the hospital, you are investing in your community," Worth said. "We need everyone's support."
Tickets to the ball are $75 each or $150 per couple.
Those willing to spend a little more -- $175 for an individual or $275 for a couple -- will also receive tickets for the patron "Sail Away" party. "Pay a little extra and you get two parties," Urhahn said.
The patron party will take place from 6-9 p.m. Oct. 19 at the home of Brad and Courtney Bedell in addition to entry to the Ball. "That's Friday, the night before the Ball," Menz said.
Also taking place in conjunction with the Hospital Ball is a raffle for the chance to win a 42-inch flat screen TV plus $5,000 cash. Tickets are available for $20 each or six for $100 at businesses in Sikeston and the surrounding communities. "Look for the signs and flyers posted in the area," Menz said.
In addition to the main raffle, each of MDMC's departments are holding their own raffles for prizes ranging from football tickets to additional paid vacation time, Menz said. "The public is welcome to come out here and purchase these, too," she said.
"The employees are working very hard to raise money," Urhahn said.