Sikeston, the defending district champion and winners of five of the last seven district titles, will have its hands full with newcomer Farmington added to the field.
However, Sikeston coach Brian James is optimistic about his team's chances.
"I think all six of our players have a goal and they all want to advance," said James. "They all want to do well individually and if that happens your team does well. We've added Farmington and that's a very strong competitor in the mix of our district. Them and Festus have some strong players so those are probably the top two team threats to us."
Sikeston's doubles team of Sam Zhao and Clayton Matthews, who won the doubles competition last year on their way to the state tournament, are seeded first this season with a 14-0 record.
Singles player Charlie Jones is seeded third with a 13-1 record.
Also competing will be Stuart Strom in singles with a 10-2 mark. In doubles, Justin Deere and Logan Hampton will compete with a 3-0 record.
The team has been off more than a week but James says the time off from matches won't affect his team much.
"The last couple days have been pretty hot and it's predicted to be pretty hot Thursday so you don't want them over-stressing too much going into districts because it's going to be a long day," said James.
Farmington's Justin Arnold is seeded first in singles while defending district champion Nik Boyer, of Festus, is seeded second.
Dexter's Thomas Fowler is seeded fourth in singles.
In doubles, Charleston's David Holley and Daniel Barnes are seeded third.