Sikeston, seeded third, took a 2-0 lead into halftime against the sixth-seeded Knightettes.
Sikeston (14-9-1) plays host St. Vincent today at 3:30 p.m. The second-
seeded Squaws defeated Kennett 6-0 in the first round Saturday.
Farmington cut the lead to 2-1 on a penalty kick to start the second half but Sikeston put the game away with three straight goals.
"We played a little more intensity and played like we really wanted to control it from the get-go," said Sikeston coach Derrick Long. "We got an early goal and controlled the tempo of the game. We had a lot of scoring chances. Abbi (Keefer) hit the post in the first half so we were getting good shots. We were able to put them away in the second half."
Sikeston got on the scoreboard when Jordi Ferrell scored on an assist from Megan Underhill at the 18:00 mark. Keefer's goal made it 2-0 on an assist from Caitlin Underwood at the 38:00 mark.
Farmington's Heather Lewis booted in the penalty kick to cut the Sikeston lead in half.
It was one of just four shots on goal by Farmington.
Sikeston put the game away from there. Jennifer Millington scored on an assist from Keefer at the 47:00 mark. Ferrell added another goal on an assist from Katie De La Rosa at the 54:00 mark.
Keefer booted in her second goal on an assist from Ferrell at the 70:00 mark.
"We played much better defensively -- we tightened up on defense and made them go out wide on us," said Long. "Today will be a real test for our defense. "St. Vincent has some speed and they push a lot of people up. They play an offensive game, so our defense will have a tough challenge."
Long said he may also get a boost with the return of Laura Atchison from a hip injury.
She has yet to be cleared by doctors, but if she is able to go she will help solidify the Lady Bulldog defense.
Top-seeded Notre Dame plays Perryville in the other semifinal today.