Sikeston scored on the first play from scrimmage and never looked back as they eventually got the mercy clock running in the third quarter.
"The kids are working hard and we're growing as a team," said Sikeston coach Steve Bays. "Everybody contributes and hopefully this is something we can build. We've got to stay humble and keeping working hard."
After holding Dexter to a punt to start the game, Sikeston's Eli Jackson took his first handoff and rumbled 78 yards for a touchdown.
In the second quarter, Jackson broke off a 41-yard touchdown run. Tanner Bryant then threw a two-point conversion pass to Niquavious Dixon to make it 14-0.
Later in the quarter, with 1:05 left to play, quarterback Jaqualin Wiggins rolled out and hit Dwayne Harris on a short pass that he turned into a 60-yard touchdown keyed by a great downfield block by Dixon.
Jackson ran in the two-point conversion to lead 22-0 at halftime.
In the third quarter, Harris caught an 8-yard pass from Bryant for a touchdown. Jackson's extra point kick make it 29-0 with 4:53 left in the third.
Following a Chris Boyd interception that he returned 27 yards to the Dexter 31, Bryant found Dixon for a 26-yard touchdown reception. Jackson's extra point kick made it 36-0 to enforce the running clock.
Dexter tacked on a score with 2:53 left in the game on Ben Mills' 5-yard quarterback keeper to cut the lead to 36-7.
Sikeston scored one last time with 27 seconds left as Bryant found Dixon on a short pass that he turned into a 75-yard touchdown to reach the final margin.
Jackson rushed for 133 yards on five carries and two scores. Harris rushed for 40 yards on six carries. Wiggins had 25 yards on two carries and Jarian Wims had four yards on two carries.
Harris also had two receptions for 68 yards, both going for touchdowns. Dixon had two receptions for 101 yards, with both also going for touchdowns.
Bryant completed 3-of-5 passes for 109 yards and three touchdowns. Wiggins completed his only pass attempt for a 60-yard touchdown.
Sikeston's freshmen will be back in action on Sept. 21 when they host Charleston. Sikeston's eighth grade team will play Kennett on Saturday morning at 10 a.m.
POPLAR BLUFF -- The Sikeston volleyball team fell to 5-4 on the season with a 25-12-, 25-18 road loss to Poplar Bluff on Thursday.
In the first set, Sikeston led 3-2 early but couldn't hold on. Poplar Bluff later went on a 10-2 run to open up a 19-8 lead.
In the second set, Sikeston fell behind early but went on a 9-2 run to pull to 14-12, but they wouldn't get any closer.
Sikeston will compete in the Perryville Tournament on Saturday.
Sikeston's junior varsity also lost in straight sets to Poplar Bluff's J.V., 25-8, 25-21.
The Portageville Lady Bulldogs volleyball team remained undefeated in Bootheel Conference play on Thursday night with a three set victory over the Kennett Lady Indians.
Portageville (11-4-1, 4-0) fought back after losing the first set 25-22 and took the second set 25-14.
Trailing 24-20 in the deciding set, the Lady Bulldogs reeled off six straight points to gain the hard fought victory.
Kellye Penn responded with a great performance on an emotional night for her to lead the team with seven kills. Lauren Kellams recorded six kills and three blocks for Portageville. Hannah Rone dished out eight assists to lead the Lady Bulldogs.
BENTON - The Kelly Lady Hawks softball wasted little time in dispatching the visiting East Prairie Eagles on Thursday afternoon with a 21-0 win in two innings.
Kelly scored seven runs in the bottom of the first inning and capped the game off with 14 runs in the second.
Senior Summer Proctor and freshman Londyn Backfisch led the offensive attack for the Lady Hawks both going 2-for-2 with three RBIs apiece. Casey Kern and Sarah Ruff also had two hits apiece for the Lady Hawks, while Brittany Ponder had a triple and four RBIs.
Kelly (15-2) will participate in the 16-team Jackson Tournament over the weekend and will face Cor Jesu at 8 a.m. on Saturday.
Kelly 21, East Prairie 0 (2 inn.)
WP - Casey Kern 5 K's, 1 H
3B - Summer Proctor (K), Brittany Ponder (K)
Multiple hitters - Kelly: Proctor 2-2, Kern 2-2, Londyn Backfisch 2-2, Sarah Ruff 2-2.