All-Region, comprised of District 1 and District 2 athletes, had Sikeston sophomore Jordi Ferrell and freshman Abbi Keefer selected.
Sikeston's Jennifer Millington, Paige Silverthorn and Ali Blurton were selected for the second team.
Ferrell scored 11 goals and led the team with eight assists in helping Sikeston reach the district semifinals with a 10-13 record.
"Even though Jordi is a sophomore, it's her first year playing for us with her injury last year," said Sikeston coach Derrick Long. "I really think she has a chance to make the all-state team and that would be amazing as a sophomore. She was a big player for us this year in controlling our midfield. We just threw her in there and we didn't have to worry about it."
Keefer pumped in 12 goals with seven assists from her forward position.
"Abbi came on strong about midseason," said Long. "Her footwork and the way she beat the defense on the ends was impressive. She set up a lot of plays for Ali."
Blurton led Sikeston with 13 goals with two assists.
"I thought Ali got slighted," said Long. "She's just a great athlete and she turned out to be a great soccer player for us. I thought she got slighted a little bit. I think she should've been first team."
Silverthorn played a new position at goalkeeper and put together a solid season with 130 saves. She also had a goal scored in a game she played away from goal.
"Paige has been on first team every year and she got second team this year because she played a new position at goalkeeper," said Long. "It was big for her to step up and take the responsibility of playing goalkeeper. It hurt her in the all-region and all-district, but it helped the team out."
Millington, a defender, scored one goal.
Millington was solid for us on defense," said Long. "I can give her praises all day. She was a leader for our team."
The same five were also honored on the All-District team, with Keefer, Ferrell and Silverthorn all making first team. Blurton and Millington made the second team.
"They were our five main players," said Long. "You could throw out a couple other names that really helped us this year, but those are the five main players. It's great for them to get recognized."
Sikeston's Ashley Angle, a freshman defender, was named honorable mention All-District. She scored three goals this year.
"That's pretty big for a freshman -- I think she was one vote short of making the second team," said Long. "We've got a pretty good nucleus coming back. Losing Paige and Ali is going to hurt us big-time, but I like what we've got coming back."