Firefighters with the Sikeston Department of Public Safety fight a fire Wednesday night at 801 Poplar Street. DPS responded at about 6:30 p.m. to a structure fire with flames and heavy flames showing. According to Lt. Bill Mygatt of Sikeston DPS, "there was significant damage. (Firefighters) were there for a couple of hours. People were home and they got out of the house. There were no injuries." A cause of the fire has not yet been determined.