The Bulldogs racked up 560 yards of total offense and were able to hold off a late rally by the Rebels, who fall to 1-1 on the season.
Sikeston amassed 447 yards on the ground while Obion County Central threw for 372 yards on a whopping 42 attempts.
The Bulldogs' offense was led by first-year starting quarterback Trey Lewis, who looked sharp in his debut, throwing for 113 yards on 8-of-13 passing while rushing for 89 yards with a touchdown.
Senior Darryl Howard led the Bulldog rushing attack with 141 yards with a touchdown. Junior James Watson had 116 yards with three touchdowns and sophomore Kyland Gross had 94 yards, including a momentum-shifting 64-yard run just before halftime to extend the Bulldogs' lead to 28-12.
Obion County quarterback Trey Phipps completed 24-of-41 passes for 330 yards with four touchdowns and one interception. Wide receiver Mason McGraw completed an option pass for 42 yards as well.
Sikeston led by as much as 42-20 after Lewis scored on a 2-yard run with 11:52 left in the game.
But Obion County's no-huddle passing attack proved to give the Bulldog defense fits down the stretch as Phipps hit McGrew on TD passes of 7 and 27 yards, the latter of which came with 3:19 left in the game.
Obion's onside kick attempt was recovered by Sikeston's Howard and the Bulldogs were able to run out the remaining time on the clock to preserve the victory.
S -- Darryl Howard 5 run (Hunter Williams kick), 8:20.
O -- Mason McGrew 8 pass from Trey Phipps (kick blocked), 11:48.
S -- James Watson 3 run (Williams kick), 7:08.
S -- Watson 43 run (Williams kick), 2:05.
O -- LaDevin Fair 1 run (pass failed), 0:48
S -- Kyland Gross 64 run (Williams kick), 0:04.
S -- Watson 1 run (Williams kick), 7:26.
O -- McGrew 15 pass from Phipps (Tanner Cary pass from Phipps), 6:35.
S -- Trey Lewis 2 run (Williams kick), 11:52.
O -- McGrew 7 pass from Phipps (Ward kick), 10:25.
O -- McGrew 27 pass from Phipps (Ward kick), 3:19.
Sikeston -- Darryl Howard 17-141, James Watson 17-116, Kyland Gross 5-94, Trey Lewis 13-89, Ray Clark 2-22, Team 3-(-15). Obion County Central -- LaDevin Fair 11-25, Trey Phipps 3-12.
Sikeston -- Trey Lewis 8-13-0 113. Obion County Central -- Trey Phipps 24-41-1 330, Mason McGrew 1-1-0 42.
Sikeston -- Robert Garces 3-59, Janeil Hatchett 3-47, Darryl Howard 2-7. Obion County Central -- Mason McGrew 7-97, Shawn Weaks 6-96, Tanner Cary 5-81, LaDevin Fair 3-68, Ward 4-30.