After taking 16 of the final 18 points to win the first set 25-13, Sikeston was able to hold off a late Portageville surge in the second, winning 25-22 to take the match.
"I thought we played great," Sikeston's Mary Eifert said. "We really gelled as a team tonight. We stayed aggressive even when things got tough and we got behind.
"We picked our heads up, came through and won."
Opening the second game, Sikeston saw Portageville break out for an trailing lead before taking a 13-7 game.
Following a timeout, however, Sikeston was able regroup and rally on Portageville, scoring nine of the game's next 11 points with a Trenice Greer ace giving Sikeston its first lead of the set at 16-15.
After Sikeston brought the set to game-point at 24-19, Portageville rallied for three straights points to try to get back in it.
Needing two straight scores to force extra-points, however, Portageville hopes at a comeback were ended when Sikeston's Quesha Howard landed a kill for match-point.
"At times we played really well and at times we just had too many mistakes," Portageville coach Barry Branscum said. "That really cost us tonight. We really showed a lot of heart in that second set.
"At times we get down and our players have a lot of heart and they fight back. We've just struggled a few times putting it all together at the end of the game."
Leading Portageville's charge was Janika McIntyre who collected seven aces, five kills and a block.
As for Sikeston, Vonteria Applewhite led the team in kills with six while adding a block. Asia Liggins and Quesha Howard tied for second second on the team with five kills apiece with the two girls adding two and one aces respectively.
With his team able to rally back in key situations, Sikeston coach Steve Beydler was pleased with his girls performance.
"In a lot of regards it's a good game for us because we came from behind twice," he said. "We had a match were they were pushing us and we had to get out of the funk we were in and just make it happen and they did. That's a positive thing."
Earlier in the evening, it was Portageville's junior varsity defeating Sikeston's junior varsity in straight sets.
After a 25-19 first set win, Portageville was able to hold off Sikeston in extra points to take the match 27-25.
Next up, Sikeston (6-14-2) will travel to Notre Dame Regional High School in Cape Girardeau, where they will play the Lady Bulldogs a week from today at 6 p.m.