(Chris Pobst photo)
With nearly 400 yards of total offense, the Eagles moved the ball up and down the field scoring on seven of their nine offensive possessions.
East Prairie quarterback Connor Scott completed 10-of-16 passes for 186 yards and four passing touchdowns. JT Aycock led the Eagles rushing attack with 86 yards on eight carries and three touchdowns.
Maurice Moore paced the Bluejays with 111 rushing yards while quarterback Jamaul Gray rushed for two touchdowns and 53 yards.
East Prairie (6-2) will play Caruthersville next week while Charleston (0-8) matches up with Malden. Caruthersville defeated Malden 42-40.