NMCC came into the game as the districts fifth seed -- one behind Potosi, who stood at the four.
Sophomore running back Malik Stevenson scored the touchdown that set up the game-winning 2-point conversion late in the third quarter. Stevenson ended up with over 100 rushing yards, as did senior Corey Guest.
NMCC quarterback Jashawn McDaniel rushed for 87 yards which pushed the Eagles' total yardage around the 400-yard mark.
Penalties and turnovers was the main cause of NMCC's slow start to the game.
Before they knew it, those mistakes had the Eagles looking up at a 21-0 disadvantage in the first quarter.
"We were just sitting around waiting for something to happen," Pixley said. "We didn't initiate anything."
Once the Eagles (4-6) finally got going, they closed the gap quickly by scoring two touchdowns before the half.
Potosi (3-7) went into the half with a 21-14 lead.
"We started to finally get in a groove and do the things we've been doing well lately," said Pixley. "We should have put more points on the board, but we made plays when we had to."
Although their lead was dwindling, the Trojans made a final push by scoring their fourth touchdown of the night to go ahead by 13 points in the third quarter.
NMCC managed to pull within seven points after scoring a touchdown and failing to convert on a 2-point conversion try, 27-20.
Late in the third, Stevenson punched in the deciding score and the Eagles converted on a crucial 2-point conversion try to give them their 1-point victory.
NMCC will take on the districts top seed, Ste. Genevieve (9-1), Wednesday at 7 p.m. at Ste. Genevieve High School.